Human tissues are composed of complex mixtures of different cell types and their biological analysis requires the procurement of pure samples of the cells of interest. Number of approaches have been used in attempts to overcome this difficulty. Laser capture microdissection (LCM) is anautomated sample preparation technology used to isolate and harvest the specific cells of interest from tissue, or organisms by direct microscopic visualization. The technique also called as laser microdissection (LMD), or laser assisted microdissection (LAM or LMD). This technology facilitates the formulation of homogenous isolates of clear cells through which DNA/RNA and various proteins can be achieved for further performingmass spectrophotometry, western blot analyses, polymerase chain reaction (PCR), and quantitative PCR. Certain benefits, such as contamination free and contact free technique, allows more efficient and accurate results, and preservance of cells with an original morphology are expected to provide good growth in the global market. Laser microdissection is now used in a large number of research fields, e.g. cancer research,neurology, forensics or climate research,and plant analysis. The method is for the time being also applied for manipulation of cell cultures or for microengraving of coverslips.A diversity of downstream applications of laser capture microdissection technique are exist includes DNA genotyping and loss-of-heterozygosity (LOH) analysis, RNA transcript profiling, proteomics discovery, cDNA library generation, and signal-pathway profiling.
Global laser capture microdissection market is segmented by product type, system type, application, and end users.By product, the global market further segmented intoinstruments, reagents and media, assay kits, consumables, and software and services.The system types segmented into infrared LCM, ultraviolet LCM,immunofluorescence LCM, and ultraviolet and infrared LCM. By considering application, LCM market segmented into diagnostics, research and development, and other applications.Whereas, by end users market might be segmented into academic and government research hospitals, institutes, pharmaceutical companies, CROs and biotechnology companies. Geographically, laser capture microdissection market can be categorized into North America, Latin America, Europe, Asia Pacific, and Middle East and Africa. By product type, instrument segment is expected to account largest share of the global LCM market during forecast period. However, consumables segment observed highest growth rate. Geographically, North America accounted largest share of the market due to availability of skilled personnel to handle LCM technology. However, Asian market is witnessing strongest growth during the forecast period due to expansion of LCM companies and R & D spending. Overall growth of the market is attributed due to strong trend in CROs and pharmaceutical companies. Hence, by end users pharmaceutical companies’ accounted largest share in global laser capture microdissection market 2014.
Increasing healthcare expenditure, growing R & D funding, and technical advantages are primary growth drivers of this market. The high-growth potential in emerging markets provide new growth opportunities and technological advancements provide new growth trends to players in the laser capture microdissection market. However,high manufacturing and maintenance cost of equipment and accessories, and lack of skilled personnel are major restraint of the Laser capture microdissection market.
Some of the major players in the laser capture microdissection market include Thermo Fisher Scientific, Inc. (U.S.), Molecular, Machines & Industries (Germany),Danaher Corporation (U.S.), Carl Zeiss AG (Germany), INDIVUMED GmbH (Germany), DeNova Sciences Pte. Ltd. (Singapore), Theranostics Health Inc. (U.S.), Ocimum Biosolutions LLC (U.S.), 3DHISTECH Ltd. (Hungary), and AvanSci Bio LLC (U.S.).
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