Dilated Cardiomyopathy Therapeutics Market is Envisaged to Hit US$328.6 mn by 2020

Transparency Market Research in a recent publication says competition in the global dilated cardiomyopathy therapeutics market is expected to grow as prominent companies strive to develop effective drugs for the treatment of dilated cardiomyopathy. For example, in February 2017, Myokardia Inc., a biopharmaceutical company, announced first time administer of MYK-491 to a batch of healthy subjects. MYK-491 is a treatment for dilated cardiomyopathy which is in Phase 1.
Keen players in the market are also focusing on collaborations, mergers, and acquisitions to consolidate their position. For example, in January 2015, Array BioPharma announced its plans of acquiring and obtaining world rights to encorafenib, which is a late stage oncology product from Novartis Pharma AG.

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As per estimates by Transparency Market Research, the global dilated cardiomyopathy therapeutics market will be worth US$328.6 mn by the end of 2020 vis-à-vis revenue, expanding at a CAGR of 4.6% from 2014 to 2020.

Growing Incidence of Cardiac Diseases to Catapult Asia Pacific to Lead Position

The segment of angiotensin II receptor blockers led amongst other drug class segments in 2013. This was followed by the segment of beta blockers. The high acceptance of angiotensin II receptor blocks is attributed to their effective therapeutic action for the treatment of dilated cardiomyopathy.
Geography-wise, the report segments the global dilated cardiomyopathy therapeutics market into: North America, Asia Pacific, Europe, and Rest of the World. North America stood as the leading regional market in 2013 mainly due to high incidence of cardiac diseases. Asia Pacific is expected to take the lead in the upcoming years as changing lifestyle resulting in increasing incidence of cardiac diseases propels growth of dilated cardiomyopathy therapeutics market.

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Efforts to Develop Specific Drugs for Dilated Cardiomyopathy Propels Growth
The alarming rise in the prevalence of congestive heart failure is one of the prominent growth drivers of the global dilated cardiomyopathy market. Dilated cardiomyopathy accounts for 30-40% of total number of congestive heart failures each year. As per statistics of the World Health Organization, 17.5 million deaths in 2013 were related to heart disorders. The increasing incidence of congestive heart diseases has created an urgent need for effective drugs and treatment, thereby benefitting the dilated cardiomyopathy therapeutics market.

Due to this, several companies have initiated to carry out clinical trials so as to develop drugs specifically for dilated cardiomyopathy. At present, there is not a single FDA approved drug specifically for dilated cardiomyopathy because of which treatment administered is the same as that for congestive heart failure. For example, Array BioPharma is carrying out phase II study for its drug ARRY-371797 for the treatment of dilated cardiomyopathy. In addition, in 2014, Celladon Corporation completed its phase II study of MYDICAR to be used for the treatment of dilated cardiomyopathy. Success of these clinical trials will positively influence the global dilated cardiomyopathy therapeutics market.

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Studies reveal that angiotensin receptor blockers such as valsartan can reduce probability of hospitalization by 28%. These drugs have also been effective for patients of systolic heart disease by reduction of deaths by 37% and also for reduced frequency of hospitalization. These factors are furthering the expansion of the global dilated cardiomyopathy therapeutics market.
On the flip side, the side effects of dilated cardiomyopathy therapeutics is leading to their declined use. Moreover, availability of implantable devices and promising gene therapy are acting as roadblocks to the market.

Growing Number of Heart Failure Incidences to Augment Demand for Dilated Cardiomyopathy Medications

Transparency Market Research has published a new report on the global dilated cardiomyopathy therapeutics market. As per the report, the global dilated cardiomyopathy therapeutics market is predicted to decline at a CAGR of -7.0% from 2014 to 2020.The report, titled ‘Dilated Cardiomyopathy Therapeutics Market - Global Industry Analysis, Pipeline Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020,’ states that the global market was valued at US$651.0 mn in 2013 and is expected to reach US$328.6 mn by 2020. Factors such as the introduction of gene and stem cell therapies for DCM and the side effects of DCM drugs are expected to restrain the global dilated cardiomyopathy therapeutics market in the years to come.

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Heart failure is primarily caused by dilated cardiomyopathy (DCM). DCM commonly develops in people aged between 20 years and 60 years. DCM is one of the primary factors, which indicates the need of heart transplantation. Approximately 30% to 40% of people genetically inherit DCM. Factors such as thyroid disorders, diabetes, a viral infection in the heart valve, and alcoholism could cause DCM. As per the Pediatric Cardiomyopathy Registry, dilated cardiomyopathy affects 6 out of 1 million children. DCM is commonly diagnosed in young children, the common diagnosis age being 2 years.

The global dilated cardiomyopathy therapeutics market is segmented on the basis of region and drug class. Some of the commonly used drug classes in DCM treatment are aldosterone antagonists, angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and beta blockers. In 2013, the angiotensin II receptor blockers (ARBs) segment held the largest share in the global dilated cardiomyopathy therapeutics market. In 2013, the beta blockers segment was the second largest segment in the global dilated cardiomyopathy therapeutics market.

The increasing incidence of congestive heart failure is expected to drive the global dilated cardiomyopathy therapeutics market in the coming few years. DCM accounts for 30% to 40% of congestive heart failure cases every year, reports suggest. Considering the increasing incidence of congestive heart failure, leading players have started initiating many clinical trial studies for DCM. Going forward, a global rise in the number of heart failure cases is expected to increase the demand for effective treatments. This is expected to drive the global dilated cardiomyopathy therapeutics market in the near future. The global market is expected to be hampered by the rising availability of implantable devices and the side effects of DCM drugs.

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Based on geography, the global dilated cardiomyopathy therapeutics market is divided into Asia Pacific, Europe, North America, and Rest of the World. In 2013, in terms of revenue, North America held a massive share in the global dilated cardiomyopathy therapeutics market due to the increasing acceptance of branded drugs and the increasing incidences of congestive heart failure here.

Some of the key companies operating in the global dilated cardiomyopathy therapeutics market are Array BioPharma, Inc., Celladon Corporation, Janssen Pharmaceuticals, Inc., Novartis International AG, Sanofi S.A., Vericel Corporation, and AstraZeneca plc.

Growing Number of Heart Failure Incidences to Augment Demand for Dilated Cardiomyopathy Medications

Dilated cardiomyopathy has led to an increase in heart failures worldwide among adults and children also giving rise to need for heart transplant. Dilated cardiomyopathy can develop between the ages of 20 and 40 years, genetic inheritance being the most common factor affecting 30%-40% of the DCM patients globally. Due to the increasing cases of heart failures, the demand for dilated cardiomyopathy drugs is expected to increase as the need for blockbuster drugs in developed countries is becoming evident.

According to a report published by Transparency Market Research, the global dilated cardiomyopathy therapeutics market is expected to witness a negative CAGR of -7% from 2014 to 2020. The global dilated cardiomyopathy market was valued at US$651 mn in 2013 and is projected to decrease to US$328.6 mn by 2020.

How can an increase in heart failure cases help drug manufacturers to develop innovative and advanced therapeutics?

According to a study, in every one million children across the globe, six are diagnosed with dilated cardiomyopathy. It is found commonly among children who are under the age of 2 years. There has also been a substantial increase in the number of heart failures among adults as well, leading to a global rise in the demand for dilated cardiomyopathy therapeutics. Of the overall congestive heart failures that occur each year, DCM comprises 30%-40%. Due to this, several leading companies have introduced clinical trials and invested for the development of therapeutics for dilated cardiomyopathy.

For instance, Cincinnati Children’s Heart Institute announced a breakthrough development on 19 May, 2016 where genetically inherited heart diseases can be diagnosed and treated with the help of biomechanics and stem cells. Similar breakthroughs are underway in the field of dilated cardiomyopathy drugs to help in the growth of the market with better techniques and medications.

What factors are responsible for the negative growth of the dilated cardiomyopathy therapeutics market?

DCM drugs segment has no drug that has been approved by FDA till date. The drugs used for the treatment of dilated cardiomyopathy and congestive heart failure are same and have no distinct formulation. DCM drugs are reported to have side effects and this has thus affected revenues from DCM therapeutics substantially. The use of devices and gene therapy that provide enhanced relief without any side effect has highly restrained the dilated cardiomyopathy therapeutics market growth globally.

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However, companies in the DCM drug market along with research organizations are working on the approval of aldosterone antagonists combined with ARBs or ACE. It is expected that these drugs will play a positive role in reducing the progress of Duchenne muscular dystrophy. This approval will help in the acceleration of sales of DCM drugs as aldosterone antagonists are one of the main additives in the formulation of DCM medications.

The increase in genericization activities of DCM drugs will also provide manufacturers with opportunities to improve their product position in the global market and also witness a positive growth of the DCM drugs market.

North America dominated the DCM drugs market in 2013 due to the demand for branded drugs and increasing heart failure cases. Asia Pacific is projected to be the fastest growing market for DCM followed by the Rest of the World owing to the per capita income increase, and improving economic standards in the region. Some of the key players operating in the global DCM drugs market are Celladon Corporation, Novartis International AG, Vericel Corporation, Sanofi S.A., AstraZeneca plc, and GlaxoSmithKilne plc.