Human tissues are
composed of complex mixtures of different cell types and their
biological analysis requires the procurement of pure samples of the
cells of interest. Number of approaches have been used in attempts to
overcome this difficulty. Laser capture microdissection (LCM) is
anautomated sample preparation technology used to isolate and harvest
the specific cells of interest from tissue, or organisms by direct
microscopic visualization. The technique also called as laser
microdissection (LMD), or laser assisted microdissection (LAM or
LMD). This technology facilitates the formulation of homogenous
isolates of clear cells through which DNA/RNA and various proteins
can be achieved for further performingmass spectrophotometry, western
blot analyses, polymerase chain reaction (PCR), and quantitative PCR.
Certain benefits, such as contamination free and contact free
technique, allows more efficient and accurate results, and
preservance of cells with an original morphology are expected to
provide good growth in the global market. Laser microdissection is
now used in a large number of research fields, e.g. cancer
research,neurology, forensics or climate research,and plant analysis.
The method is for the time being also applied for manipulation of
cell cultures or for microengraving of coverslips.A diversity of
downstream applications of laser capture microdissection technique
are exist includes DNA genotyping and loss-of-heterozygosity (LOH)
analysis, RNA transcript profiling, proteomics discovery, cDNA
library generation, and signal-pathway profiling.
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Global laser capture
microdissection market is segmented by product type, system type,
application, and end users.By product, the global market further
segmented intoinstruments, reagents and media, assay kits,
consumables, and software and services.The system types segmented
into infrared LCM, ultraviolet LCM,immunofluorescence LCM, and
ultraviolet and infrared LCM. By considering application, LCM market
segmented into diagnostics, research and development, and other
applications.Whereas, by end users market might be segmented into
academic and government research hospitals, institutes,
pharmaceutical companies, CROs and biotechnology companies.
Geographically, laser capture microdissection market can be
categorized into North America, Latin America, Europe, Asia Pacific,
and Middle East and Africa. By product type, instrument segment is
expected to account largest share of the global LCM market during
forecast period. However, consumables segment observed highest growth
rate. Geographically, North America accounted largest share of the
market due to availability of skilled personnel to handle LCM
technology. However, Asian market is witnessing strongest growth
during the forecast period due to expansion of LCM companies and R &
D spending. Overall growth of the market is attributed due to strong
trend in CROs and pharmaceutical companies. Hence, by end users
pharmaceutical companies’ accounted largest share in global laser
capture microdissection market 2014.
Increasing
healthcare expenditure, growing R & D funding, and technical
advantages are primary growth drivers of this market. The high-growth
potential in emerging markets provide new growth opportunities and
technological advancements provide new growth trends to players in
the laser capture microdissection market. However,high manufacturing
and maintenance cost of equipment and accessories, and lack of
skilled personnel are major restraint of the Laser capture
microdissection market.
Some of the major
players in the laser capture microdissection market include Thermo
Fisher Scientific, Inc. (U.S.), Molecular, Machines & Industries
(Germany),Danaher Corporation (U.S.), Carl Zeiss AG (Germany),
INDIVUMED GmbH (Germany), DeNova Sciences Pte. Ltd. (Singapore),
Theranostics Health Inc. (U.S.), Ocimum Biosolutions LLC (U.S.),
3DHISTECH Ltd. (Hungary), and AvanSci Bio LLC (U.S.).
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